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KMID : 1041220030450010025
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Journal of Sericultural and Entomological Science
2003 Volume.45 No. 1 p.25 ~ p.30
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A useful material isolation from the Bombycis corpus (Beauveria bassiana) growing of the silkworm, Bombyx mori L.
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Jung I-Yeon
Nam Sung-Hee
Hong In-Pyo
You Seoung-Hun
Kwon Hak-Cheol
Lee Kang-Ro
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Abstract
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This study was carried out to investigate active constituents of Bombysis corpus on the neurite outgrowth from PC 12 cells led to isolate three new and a known sphingolipids from the n-hexane soluble portion and five amines from the butanol soluble portion of its methanol extract. On the basis of spectroscopic data, their structures have been elucidated as (4E,6E,2S,3R)-2-N-eicosanoyl-4,6-tetradecasphingadienine, (4E,2S,3R)-2-N-eicosanoyl-4-tetradecasphingenine,(4E,6E,2S,3R)-2-N-docosanoyl-4,6-tetradecasphingadienine,(4E,6E,2S,3R)-2-N-docosanoyl-4,6-tetradecasphingadienine,(4E,2S,3R)-2-N-octadecanoyl-4-tetradecasphingenine, 1,7-dimethyl-xanthine, uracil, urea, betaine and tyrosine, respectively. The neurite outgrowth activities of these compounds were examined in PC12 cells by measuring the length of neurites. These compounds promoted neurite outgrowth in PC12 cells significantly.
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KEYWORD
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Bombycis corpus, PC12 cells, Silkworm, Beauveria bassiana
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